Nanoparticles have distinct properties that could be useful in a wide range of applications. In the biomedical field, the development of nanoparticle therapeutics is being researched. Biomolecules including proteins will associate with the nanoparticle surface and adsorb to form the protein corona. This nanoparticle protein interaction leads to the formation of a nanoparticle-protein complex, referred to as the nanoparticle-protein corona. Nanoparticles could be particularly useful by acting as protein transporters in protein drug delivery. The nanoparticle protein corona influences the nanoparticle properties, including its targeting capabilities, cytotoxicity, and immunotoxicity. The nanoparticle protein corona can also influence the nanoparticle surface’s biological properties, such as its reactivity. However, our current level of our understanding of nanoparticle protein interactions is incomplete. This poster outlines a strategy for probing nanoparticle interactions with proteins.