Venkata Eluri

First Name: 
Venkata
Last Name: 
Eluri
Mentor: 
Dr. James Duban
Abstract: 
The fnr (fumarate and nitrate reductase) gene of Escherichia coli encodes the FNR (Fumarate and Nitrate reductase Regulatory) protein that expresses various genes involved in the anaerobic respiratory pathways of E. coli. FNR is a member of a growing family of CRP-related regulatory proteins that have a DNA-binding domain based on the helix-turn-helix structural motif. FNR is contingent to autoregulation and repression by glucose, especially during anaerobic respiration. When the principal electron acceptor, O2, is no longer available, FNR represses the synthesis of enzymes involved in aerobic respiration, while increases synthesis of enzymes needed under conditions of anoxia. I have enrolled in a guided-studies course, in which I have chosen to research several of Dr. Stephen Spiro’s publications. This course was a valuable learning experience in various aspects of the research setting.
Poster: 
FNR is an anaerobic regulatory protein in E. coli that functions similar to CRP and chelating agents
Year: 
2021