Changes in maternal responsiveness and sensitivity tend to transmit over multiple generations since these changes alter the epigenome transgenerationally. However, maternal behavior is dynamic and can change because of the organism’s life experiences or environmental alterations around it. The researchers explored plasticity in the brain's pathways and how they associate with different maternal behavior outcomes observed in the laboratory rodents. Furthermore, the studies provide insight into hormonal and nonhormonal pathways that induce DNA methylation changes, leading to epigenome alterations. This research examines laboratory rodents and humans to understand mechanisms that contribute to lifelong plasticity and maternal behavior transmission transgenerationally.