Currently, there is no early indication for ovarian cancer, which is asymptomatic in its early stages with a survival rate that gradually drops from 90% in its early stages to 17% in the later stages. Methods for early detection are vital; final stages have no successful treatment. This project explores informative markers for detection of early stages of epithelial ovarian cancer (EOC). We ask what changes occur in TRPV6 expression and whether use of an improved thermocouple-sensitive material in our novel 2016 reported micro-thermal sensor (MTS) will detect EOC early stages. Authenticated EOC transitioning cell lines will be used as a test-bed. TRPV6 expression will be determined using Western and Elisa methods. Both the original and improved MTS will probe to provide quantitative measurements of laser-induced temperature differences, Statistical-relevant data added to the EOC profile. We expect the improved MTS will detect thermal conductivity differences in early transitions - normal to malignant and TRPV6 expression will increase. Future steps include obtaining empirical data to demonstrate significant differences in early stage thermal conductivities. If successful, we will have identified thermal markers for early EOC, screening and diagnosis, as well as introduced a prototype device – MTS – for routine EOC laparoscopy.