The GP1b complex, originating from the GP1BA (Glycoprotein Ib Platelet Subunit Alpha), GP1BB (Glycoprotein Ib Platelet Subunit Beta), and GP9 (Platelet Glycoprotein IX) genes, located on chromosome 17/22/3 in humans and 23/8/23 in Zebrafish respectively, plays an integral role in hemostasis and thrombosis. The complex forms a membrane receptor complex `found on platelets, and is responsible for initiating platelet aggregation and agglutination post-Von Willebrand Factor interaction. The following review of literature will focus on the phenotypic outcomes of genetically altering the respective DNA and creating a GP1B mutant amongst other relevant literature. The review will also briefly discuss the history and laboratory outcomes of the Zebrafish model, review the genetic products of the aforementioned genes and their respective phenotypes, and stipulate the probable outcomes of creating a GP1b mutant in the Zebrafish model.