Grace Huang

First Name: 
Grace
Last Name: 
Huang
Mentor: 
Dr. Warren Burggren
Abstract: 
Planaria (Dugesia tigrina) are regenerative flatworms that are commonly used in stem cell research and used as a simplified model of the human nervous system. This research aims to study the effects of ethanol alcohol on learning and memory on planaria, and, in the long run, to understand the negative effects of drinking on the human brain. For this experiment, planarians were divided between "familiarized" and "unfamiliarized" groups. The "familiarized" group was trained on a rough surface in which they demonstrated strong negative thigmotaxis and the "unfamiliarized" group was trained on a smooth surface. After 10 days of positive reinforcement using beef liver, both groups were tested on rough surfaces to observe if the "unfamiliarized" group displayed less negative thigmotaxis towards the rough surface. Successfully trained planaria would be used in testing the effects of different levels of alcohol (0%, 0.01%, 0.08%) on memory and learning. As of now, only preliminary results from the training phase has been completed. We have found the "familiarized" group was comparatively less active and curious on the rough surface compared to the "unfamiliarized" group. These unexpected results are speculated to occur due to overexposing the "familiarized" group to the rough surface.
Poster: 
Effect of Ethanol on Memory and Learning in Dugesia tigrina