Alcohol and cannabis are two of the most commonly used substances, and when an individual engages in hazardous patterns of substance use, they may put themselves at risk for substance-related problems. Different age groups display varying degrees of substance use and related problems, with one of the most at-risk populations being emerging adults (i.e., 18-25 years old). Extant literature has shown that various anxiety and depressive variables relate to substance use; one anxiety-related variable that necessitates more research is anxiety sensitivity (AS; the fear of anxiety-related symptoms and its consequences). The current study investigated potential moderational effects of AS on coping-motive and anxiety relations with problematic substance use. It was hypothesized that AS will act as a moderator across both forms of substance use problems, such that AS would strengthen coping-motive and anxiety associations with problematic alcohol and cannabis use. Participants were emerging adult students who endorsed past year alcohol or cannabis use and completed self-report measures via online survey. Contrary to hypotheses, alcohol and cannabis use motive interactions with AS on substance use problems mostly involved motives other than coping, and AS moderated all motive/anxiety relations with substance use problems such that the associations were weakened rather than strengthened.